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Marco Tamietto receives ERC Proof of Concept Grant for PRISM project

Published: 18th January 2024 Last updated: 18th January 2024

The PRISM project focuses on addressing key challenges in neurosurgical training involving non-human primates (NHPs), especially within the context of the 3Rs framework (Replacement, Reduction, Refinement) endorsed by the EU. The project aims to develop the first hyper-realistic model for hands-on surgical training in NHPs, collaborating with UpSurgeOn, a company specializing in 3D simulation for human neurosurgery.

Marco Tamietto: "PRISM's goal is to create a safe and ethical training environment for young researchers to hone their surgical skills in craniotomies without experimenting on living animals. This initiative is expected to reduce the risk of irreversible neurological damage during surgery and align with the ethical principles of the 3Rs framework. The project aims to set a new standard in NHP neurosurgical education with a global impact, fostering career development, enhancing animal welfare, and improving research quality​​."

Bridging a gap in neurosurgical training

PRISM addresses a major gap in neurosurgical training paradigms by providing a solution that is both ethical and practical. The use of hyper-realistic models for surgical training on NHPs has significant societal implications:

  • Ethical Training: It promotes ethical training practices by reducing the need for direct experimentation on living animals, aligning with the 3Rs principles.
  • Enhancing Animal Welfare: The project contributes to animal welfare by minimizing the use of live animals in surgical training and research.
  • Quality of Research: By providing a platform for safe and effective training, PRISM enhances the quality of research and surgical outcomes in the field of neuroscience.
  • Career Development: The project fosters the career development of junior researchers by providing them with essential skills and experience in a risk-free environment.
  • Global Impact: The successful implementation of PRISM has the potential to set new global standards in neurosurgical education and animal welfare practices​​.

How will the grant be deployed?

The total amount awarded for the PRISM project is €150,000 (the maximum possible), distributed between Tilburg University (€90,000) and UpSurgeOn Srl (€60,000). This budget will be used for various aspects of the project. Firstly, significant funds will be dedicated to the development and production phase. This involves the creation of hyper-realistic 3D anatomical skull models of NHPs, specifically designed to enhance surgical training. Secondly, resources have been set aside for the initiation and execution of pilot courses for trainees. Another crucial aspect is the allocation of funds towards commercialization strategies. This includes the formulation and implementation of effective strategies to introduce both the developed anatomical devices and the training courses to the market. Furthermore, a significant emphasis will be placed on collaboration and expertise. This involves integrating the collective efforts of a scientific team comprising neuroscientists, neuroanatomists, and neurosurgeons, alongside a development team consisting of 3D artists and app developers. Lastly, the budget will be allocated to human resources and personnel.