CoRPS Center of Excellence

Research of the Department Medical and Clinical Psychology is embedded in CoRPS.

Projects Cardiovascular disorders

Current projects

WEBCARE

WEB-based distress management program for implantable CARdioverter dEfibrillator patients (WEBCARE)

Summary;

The primary aim of the WEBCARE trial is to evaluate the effects of a web-delivered intervention (6 online lessons over 12 weeks) targeting symptoms of anxiety, depression, and ICD concerns with respect to enhancing ICD acceptance and quality of life and its cost-effectiveness. Secondary outcomes are investigating whether psychological (e.g. Type D personality and positive affect) and clinical factors (e.g. heart failure and ICD indication) moderate the effect of the intervention, and whether the intervention influences physiological parameters (e.g. the incidence of ventricular arrhythmias and the cortisol awakening response). Patient assessments are performed at baseline (time of implantation), 3, 6, and 12 months.

Study participants are consecutively implanted ICD patients with a first-time ICD, age between 18-75 years, having internet access and a requisite level of internet skills. Patients are recruited from six referral hospitals in the Netherlands.

ADJUST-LVAD project

Adjustment following implantation of a left ventricular assist device in heart failure patients and their partners. A prospective, multi-center, observational study (ADJUST-LVAD)

Summary:

Heart failure is a severe clinical syndrome that despite significant advances in its treatment over the past two decades, continuous to be a major source of morbidity and mortality. Due to a shortage of donor hearts, alternative solutions, including innovations in (left) ventricular assist device (LVAD) technology have been sought and currently established as a bridge to heart transplantation for patients with advanced heart failure. Due to the successful use of LVADs and the likely increase in their use in the future it is important to understand the impact of device therapy on patients and their families. However, little is known at this moment about the role of psychological factors, relative to clinical factors and disease severity, in determining health outcomes, such as quality of life, functional status and morbidity, in patients treated with LVADs. The aims of the prospective, multi-center observational study are to examine the changes in health status (functional status and Quality of Life) and emotional distress over time in patients following LVAD implantation and their partners, and to investigate the determinants of morbidity and mortality in LVAD patients using a longitudinal approach.

NCCM project

The Role of Psychosocial Factors in the Management and Progression of Noncompaction Cardiomyopathy: An Exploratory Study (NCCM studie)

  • Researcher: Corline Brouwers
  • Funding organization: Netherlands Organisation for Scientific research, NL
  • Start project: 2012
Summary;
Noncompaction cardiomyopathy (NCCM) is a rare disease that is unique in its presentation, treatment and psychosocial consequences compared to other cardiac diseases due to the relatively young age of the patients, the need for genetic testing and family screening and the potential risk of sudden cardiac death. These clinical characteristics and treatments can be associated with various physical, social, and emotional challenges that have not yet been documented in NCCM. The aim of the NCCM project is to examine the psychosocial consequences of NCCM and to establish whether psychosocial factors are of predictive value in the clinical course of patients with NCCM. The study consists of a cross-sectional survey using a case-control design and a longitudinal study with a 2-year follow-up for adverse cardiac-related outcomes. The study population consists of a cohort of (N=45) NCCM patients, which will be age-matched with patients having familial hypercholestrolemia and patients with cardiomyopathy and a history of heart failure.

THORESCI

Tilburg Health Outcomes Registry of Emotional Stress in Coronary Intervention (THORESCI)

  • Researcher: Nina Kupper
  • Funding Organization: NWO
  • Start project: 2013

Summary:

Rationale: Percutaneous coronary interventions (PCI) have become mainstay treatment for acute coronary artery disease and the number of patients receiving PCI is vastly growing. Psychological risk factors are important in determining prognosis after PCI, and undergoing PCI may increase the risk of low mood. To date, studies have examined single psychological risk factors, without taking into account their relatedness. Although the detrimental effects of psychological risk factors on cardiovascular prognosis are known, the mechanisms through which they exert these effects are yet unclear. It is to be expected that not one but multiple biological (inflammation, endothelial dysfunction) and behavioural (coping styles, poor self-care, consultation behaviour) pathological processes play a role, and that these processes interact with each other. In PCI patients, the mechanisms linking psychological risk to poor prognosis are still to be investigated.

Objective: (1) To examine the adherence to the prevention and PCI guidelines and the effects thereof on long term prognosis in PCI patients. (2) To examine effects of clustering psychological risk factors on several networks of potentially mediating mechanisms and long term outcomes in a large sample of PCI patients.

REMOTE-CIED study

Remote Monitoring of Heart Failure Patients with a Cardiovascular Implantable Electronic Device: The Patient Perspective

  • Researcher: Mirjam Mastenbroek
  • Start project: 2013
  • Summary:
    Current project (gestart in 2013) (deze had Mirjam ook al naar je gemaild) The primary objective of this multicenter, randomized controlled study is to evaluate the effect of Remote Patient Monitoring (RPM) + in-clinic follow-up versus in-clinic follow-up only on patient-reported health status and device acceptance in the first 2 years after implantation with an ICD/CRT-D device. The secondary objectives are: 1) to identify subgroups of patients who are or are not satisfied with RPM due to specific clinical and psychological factors, and 2) to investigate the cost-effectiveness of RPM + in-clinic follow-up compared to in-clinic follow-up only.
  • Funding: Boston Scientific
  • Betrokken CorPS onderzoekers: Versteeg, Pedersen, Mastenbroek personality and patient factors and sexual functioning/the quality of sexual life.

Patient-Centered Outcomes Recovery from Treating PAD

Patient-Centered Outcomes Recovery from Treating PAD: Investigating Trajectories. Project carries out with the Mid America Heart Institute, Kansas City, MO & Yale University 

  • Researcher: Kim Smolderen
  • Funding Organization: PCORI (Patient-Centered Outcomes Research Institute), Washington, USA
  • Start project: 2012

Biobehavioral triggers of cardiac events

Biobehavioral triggers of cardiac events

Psychosocial determinants of self-management

Psychosocial determinants of self-management in chronic heart failure patients’

The psychological impact of device therapy

The psychological impact of device therapy for the treatment of heart disease’. VIDI - Innovational Research Incentive (personal)

  • Researcher: Susanne Pedersen
  • Start project: 2010
  • Funding organization: Netherlands Organisation for Scientific research, NL

Utilization of implantable cardioverter DEFIBrillator therapy

'Utilization of implantable cardioverter DEFIBrillator therapy in the treatment of heart disease: Clinical and psychological outcomes in WOMEN (DEFIB-WOMEN Study)'

  • Researcher: Susanne Pedersen
  • Start project: 2010
  • Funding organization: Danish Heart Foundation, Denmark

Portraying Patients with Peripheral Arterial Disease

‘Portraying Patients with Peripheral Arterial Disease (PAD)’. VENI - Innovational Reseach Incentive (personal)

  • Researcher: Kim Smolderen
  • Start project: 2010
  • Funding organization:  Netherlands Organisation for Scientific research, NL

Mood and personality

Mood and personality as precipitants of arrhythmia in patients with an Implantable cardioverter Defibrillator: A prospective Study (MIDAS)

  • Researcher: Madelein Hoogwegt
  • Start project: 2010
  • Funding organization: Netherlands Organisation for Scientific research, NL

Adjustment following implantation

Adjustment following implantation of a left ventricular assist device in heart failure patients and their partners. A prospective, multi-center, observational study (ADJUST-LVAD)

Perspectives on percutaneous coronary intervention

Perspectives on percutaneous coronary intervention: More than just coronary arteries? 

Summary:

This project focuses on the psychological well-being of patients treated with percutaneous coronary intervention (PCI, or coronary stenting), the impact of psychological distress on long-term prognosis, potential underlying mechanisms, and the occurrence and consequence of attrition bias in prospective cohort studies.

WEB-based distress management program

WEB-based distress management program for implantable CARdioverter dEfibrillator patients’ (WEBCARE)

  • Researchers: Susanne Pedersen, Spek, Van de Broek
  • Start project: 2009
  • Funding organization: The Netherlands Organisation for Health Research and Development

WEB-based distress management program

WEB-based distress management program for implantable CARdioverter dEfibrillator patients (WEBCARE)

Completed projects

PSYHEART-CRT

The influence of PSYchological factors on health outcomes in HEART failure patients treated with Cardiac Reynchronisation Therapy: A prospective, single-center, observational study

  • Researcher: Henneke Versteeg
  • Start project: 2009
  • Funding organization: Netherlands Organisation for Health Research and Development (ZonMw)
  • Summary:
    The primary objective of this single center study was to examine whether psychological factors play a moderating role in the association between the objectively assessed CRT response (i.e., reverse remodeling) and patient-reported outcomes.
  • Betrokken CorPS onderzoekers: Versteeg, Pedersen.

Depression and inflammation: A life perspective

Depression and inflammation: A life perspective

Type D personality

Type D personality across general population and coronary patient samples in Iceland. Implications for cardiovascular health

  • Researcher: Erla Svansdóttir
  • Project completed in: 2012

Anxiety and depression in coronary heart disease

Anxiety and depression in coronary heart disease: A closer look

  • Researcher: Annelieke Roest
  • Project completed in: 2011

Location and Diffuseness of Lower Extremity

Location and Diffuseness of Lower Extremity Peripheral Arterial Lesions: Documenting Associated Cardiovascular Risk and Symptom Profile

The effects of a self-efficacy based exercise

The effects of a self-efficacy based exercise intervention on physical activity, cardiovascular outcomes and health status in inactive patients with type 2 Diabetes Mellitus

  • Researcher: Marion van der Heijden
  • Project completed in: 2009

The complexity of psychological factors in cardiac disease

The complexity of psychological factors in cardiac disease

  • Researcher: Aline Pelle
  • Project completed in: 2009

Fatigue at the interface between body and mind

Fatigue at the interface between body and mind in chronic heart failure patients

  • Researcher: Robert Smith
  • Project completed in: 2009

Integrated telemonitoring and telecare

‘Integrated telemonitoring and telecare for patients with heart failure: A randomized controlled trial in primary care. INTEL-HF’

Anxiety in implantable defibrillator treatment

Anxiety in implantable defibrillator treatment: Vulnerability factors and clinical consequences

  • Researcher: Christa van den Broek
  • Project completed in: 2008

Health outcomes in chronic heart failure

Health outcomes in chronic heart failure: The role of type-D personality

  • Researcher: Angélique Schiffer
  • Project completed in: 2008

Titel project no. 06-4-B505-A924-22283F

Titel project no. 06-4-B505-A924-22283F

  • Researcher: Susanne Pedersen
  • Project completed in: 2006
  • Funding organization: Danish Heart Foundation, Denmark

‘Personality and Vulnerability to Heart Disease’

‘Personality and Vulnerability to Heart Disease’ VICI - Innovational Research Incentive (personal)

  • Researcher: Johan Denollet
  • Project completed in: 2005
  • Funding organization: Netherlands Organisation for Scientific research, NL

Mood and Personality as Precipitants of Arrhythmia

Mood and Personality as Precipitants of Arrhythmia in Patients with an Implantable Cardioverter Defibrillator: A Prospective Study (MIDAS)’ VENI - Innovational Research Incentive Titel project (personal)

  • Researcher: Susanne Pedersen
  • Project completed in: 2005
  • Funding organization: Netherlands Organisation for Scientific research, NL