Promotie S.C.M. ten Eikelder MSc

Radiation therapy is one of the main treatment modalities for various different cancer types. One of the core components of personalized treatment planning is the inclusion of patient-specific biological information in the treatment planning process. Using biological response models, treatment parameters such as the treatment length and dose distribution can be tailored, and midtreatment biomarker information can be used to adapt the treatment during its course. These additional degrees of freedom in treatment planning lead to new mathematical optimization problems. This thesis studies various optimization aspects of biologically-based treatment planning, and focuses on the influence of uncertainty. Adjustable robust optimization is the main technique used to study these problems, and is also studied independently of radiation therapy applications.

Stefan ten Eikelder (Eindhoven, the Netherlands, 1994) received his Bachelor’s degree in Econometrics and Operations Research from Tilburg University in 2015, followed by a Master’s degree (2017) and a Research Master degree (2018), both in Operations Research, from the same university. In September 2018, he became a PhD candidate in Operations Research at Tilburg University. Stefan carried out his research in collaboration with researchers at Massachusetts General Hospital / Harvard Medical School (Boston, USA), which he has visited several times.

• Locatie: Cobbenhagen building, Aula
• Promotores: prof. dr. D. den Hertog, prof. dr. T. Bortfeld