Bio

I’m passionate about health and statistics, and aim to combine these two to make my contribution to health care. My research focuses on improving and developing efficient statistical decision procedures for clinical trials, such that fewer participants are needed to test the effects of new treatments. My work is supported by an NWO Research Talent grant “Making the most of clinical trials: Increasing efficiency using novel Bayesian methods for information sharing within and between trials”. Currently, I am developing a Bayesian framework to make decisions based on multiple binary outcomes, while monitoring incoming data (i.e. in an adaptive trial).

Recent publications

  1. A Bayesian multivariate framework for analysis and decision-making wi…

    Kavelaars, X. M. (2023). A Bayesian multivariate framework for analysis and decision-making with binary outcome variables. Gildeprint.
  2. Bayesian multilevel multivariate logistic regression for superiority …

    Kavelaars, X., Mulder, J., & Kaptein, M. (2023). Bayesian multilevel multivariate logistic regression for superiority decision-making under observable treatment heterogeneity. BMC Medical Research Methodology, 23(1), Article 220.
  3. Interim results from CAR-Study B - An ongoing randomized trial on the…

    Schimmel, W., Verhaak, E., Hanssens, P., Kavelaars, X., Mulder, J., Kaptein, M., Sitskoorn, M., & Gehring, K. (2022). Interim results from CAR-Study B: An ongoing randomized trial on the effect of SRS or WBRT on cognitive performance in patients with 11-20 brain metastases. Neuro-Oncology, 24(Suppl 2), ii24-ii24.
  4. Multiple imputation in data that grow over time - A comparison of thr…

    Kavelaars, X. M., Buuren, S. V., & Ginkel, J. R. V. (2021). Multiple imputation in data that grow over time: A comparison of three strategies. arXiv.org. https://arxiv.org/abs/1904.04185
  5. Decision-making with multiple correlated binary outcomes in clinical …

    Kavelaars, X., Mulder, J., & Kaptein, M. (2020). Decision-making with multiple correlated binary outcomes in clinical trials. Statistical Methods in Medical Research, 29(11), 3265-3277.

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